C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07C 69/00 (2006.01) C07C 233/11 (2006.01) C07C 233/58 (2006.01) C07C 233/61 (2006.01) C07C 233/63 (2006.01) C07C 237/22 (2006.01) C07C 255/29 (2006.01) C07C 309/27 (2006.01) C07C 323/41 (2006.01) C07D 207/16 (2006.01) C07D 209/16 (2006.01) C07D 209/20 (2006.01) C07D 211/60 (2006.01) C07D 217/26 (2006.01) C07D 307/52 (2006.01) C07D 307/68 (2006.01) C07D 405/12 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2
Patent
CA 2128998
2128998 9316982 PCTABS00025 Compounds of formula (I) wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a carbonyl, sulphonyl or sulphinyl group or -C(O)-CH2- (in which the carbonyl group is bonded to Y), provided that at least one of W and X contains carbonyl, Y is R7-O- or R7-N(R8)- (wherein R7 is H or C1 to C15 hydrocarbyl, up to two carbon atoms of the hydrocarbyl moiety optionally being replaced by a nitrogen, oxygen or sulphur atom provided that Y does not contain a -O-O- group, and R8 is H, C1 to C3 alkyl, carboxymethyl or esterified carboxymethyl), Z is selected from (i) -O-R9, (ii), (iii), (iv), wherein R9-R13, Q, Q', G, T, A, B, a and b are as defined in claim 1; or Z is absent and W is H, R1 is H, methyl, halo, carboxy, esterified carboxy, amidated carboxy, carboxymethyl, esterified carboxymethyl or amidated carboxymethyl, R2 is selected from the groups recited above for R1; R3 and R4 (or each R3 and R4 group, when m or n is 2 or more) are independently selected from halo, amino, nitro, cyano, sulphamoyl, C1 to C3 alkyl, C1 to C3 alkoxy, carboxy, esterified carboxy and amidated carboxy, R5 and R6 are independently selected from H and the groups recited above for R3; m, n = 0 to 4, with provisos as given in claim 1 and pharmaceutically acceptable salts thereof, are ligands at cholecystokinin and/or gastrin receptors.
Bodkin Michael J.
Buck Ildiko M.
Davies Jonathan M. R.
Dunstone David J.
Harper Elaine A.
James Black Foundation Limited
Swabey Ogilvy Renault
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