C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 13/00 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07C 323/67 (2006.01) C07H 21/00 (2006.01) C07K 1/13 (2006.01) C07K 5/083 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/14 (2006.01) C07K 7/64 (2006.01) C07K 14/475 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2232315
The invention concerns novel compounds of general formula (I), M-L, in which M stands for a radioisotope of Tc or Re and L stands for a ligand of general formula (II) R1S-CR2R3-(CR4R5)n=1,2-S-CHR6-CHR7-SO2-NH-(CR8R9)m=1,2-CO-B in which R1, R2, R3, R4, R5, R6, R7, R8, and R9 can have different meanings and B stands for a further group which is suitable for the dative bond of metal ions and for the coupling to selectively concentrating compounds. The novel compounds are used for complexing technetium and rhenium and are applied in medical diagnostics and therapy.
L'invention concerne de nouveaux composés de formule générale (I) M -L, dans laquelle M représente un radio-isotope de Tc ou de Re, et L un ligand de formule générale (II) R?1¿S-CR?2¿R?3¿-(CR?4¿R?5¿)¿n=1,2?-S-CHR?6¿-CHR?7¿-SO¿2?-NH-(CR?8¿R?9¿)¿m=1,2?-CO-B dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, et R?9¿ peuvent avoir différentes notations et où B représente un autre groupe, qui d'une part convient pour la liaison dative d'ions métal et d'autre part pour le couplage avec des composés à concentration sélective. Ces nouveaux composés permettent la complexation du technétium et du rhénium et sont utilisés dans le domaine médical pour le diagnostic et la thérapeutique.
Dinkelborg Ludger
Erber Sebastian
Hilger Christoph Stephan
Kramp Wolfgang
Platzek Johannes
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat
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