Biodegradable glass compositions and methods for radiation...

C - Chemistry – Metallurgy – 03 – C

Patent

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Details

C03C 3/068 (2006.01) A61K 9/16 (2006.01) A61K 41/00 (2006.01) C03C 3/15 (2006.01)

Patent

CA 2361573

A nonradioactive glass in particulate form adapted for radiation therapy in a mammal comprise a biodegradable rare earth-lithium borate glass material of a specified composition which, upon being subjected to an effective amount of neutron irradiation, will produce a beta or gamma emitting radioisotope, the radioisotope being distributed throughout the glass material, the glass upon being introduced into a body fluid for radiation therapy being adapted to react therewith causing the radioisotope to form an insoluble compound on the surface of the glass material which is retained in the glass material and thereby prevented from escaping from the treatment site. Radioactive glasses and methods for carrying out radiation therapy with such radioactive glasses are also disclosed.

Du verre non radioactif sous forme particulaire adapté à la radiothérapie chez un mammifère comprend un matériau de verre biodégradable au borate de lithium des terres rares d'une composition déterminée qui, lorsqu'il est soumis à une quantité efficace d'irradiation par les neutrons, produit systématiquement un radio-isotope émettant des particules bêta ou gamma, ce radio-isotope étant réparti dans toute la structure du matériau de verre. Lorsqu'en vue d'une radiothérapie, on introduit dans un fluide corporel ce verre qui est adapté pour réagir avec ledit fluide corporel, la réaction entraîne le radio-isotope à former un composé insoluble à la surface du matériau de verre qui est retenu dans ledit matériau de verre et qui ne peut par conséquent pas s'échapper du site de traitement. Des verres radioactifs et des procédés associés permettant de mettre en oeuvre la radiothérapie avec de tels verres radioactifs sont également décrits.

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