Biodegradable intravitreal tyrosine kinase inhibitors implants

Details Biodegradable intravitreal tyrosine kinase inhibitors implants Biodegradable intravitreal tyrosine kinase inhibitors implants

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2565221

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.

L'invention concerne des implants intra-oculaires biocompatibles comprenant un inhibiteur de tyrosine kinase ainsi qu'un polymère biodégradable efficace pour faciliter la libération de l'inhibiteur de tyrosine kinase dans le vitré d'un oeil sur une durée prolongée. Les agents thérapeutiques des implants peuvent être associés à une matrice polymère biodégradable, telle qu'une matrice sensiblement exempte d'alcool polyvinylique. Les implants peuvent être placés dans un oeil afin de traiter ou de réduire l'apparition d'une ou de plusieurs affections oculaires, telles que les affections d'une région oculaire postérieure.

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