A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/00 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01)
Patent
CA 2621395
This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus (100) includes a spinning disk (105) containing a reservoir (708) in the center thereof and a flat inclined surface. The apparatus optionally includes serrations (712) and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
L'invention concerne un appareil et un procédé permettant de produire des microparticules contenant des agents actifs sur le plan pharmacologique et des polymères biodégradables. L'appareil (100) comprend un disque tournant (105) contenant un réservoir (708) en son centre et une surface inclinée plate. L'appareil comprend éventuellement des indentations (712) et/ou une surface plate sous le pourtour du disque qui est parallèle à l'axe rotatif du disque. L'invention concerne également un procédé permettant de produire, à l'aide de l'appareil à disque tournant, des microparticules contenant des agents actifs sur le plan pharmacologique. L'invention concerne en outre des formulations contenant des agents actifs sur le plan ophtalmique ainsi que des formulations présentant des taux de libération d'ordre zéro.
Barlow Darren E.
Mcdonough Joseph A.
Persyn Joseph T.
Slovin Elliot M.
Vail Neal K.
Bennett Jones Llp
Slovin Elliot M.
Southwest Research Institute
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