C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/30 (2006.01) A61K 31/365 (2006.01) A61P 35/00 (2006.01) C07C 271/22 (2006.01) C07D 309/32 (2006.01)
Patent
CA 2401160
The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.
L'invention concerne des nouvelles compositions de composés de discodermolide biologiquement actifs, pouvant être utilisées de manière avantageuse pour l'immunomodulation et/ou le traitement du cancer. Les composés décrits dans cette invention sont utilisés dans le traitement du cancer comme polymérisateurs de tubuline et comme agents de stabilisation microtubulaire. L'invention concerne également l'identification des régions de la molécule de discodermolide qui sont responsables de certains aspects de la bioactivité des composés de discodermolide.
Gunasekera Sarath P.
Isbrucker Richard A.
Longley Ross E.
Paul Gopal K.
Pomponi Shirley A.
Harbor Branch Oceanographic Institution Inc.
Mbm Intellectual Property Law Llp
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