G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2667063
The present invention relates to a method for determining a risk of a phospholipidotic compound for inducing mitochondrial toxicity which is associated with drug-induced phospholipidosis, comprising a) measuring the level of PAG in a body flui sample, b) comparing the level of determined PAG with the level of PAG of a control wherein an increased level of PAG in comparison with that control is indicative that said compound induces mitochondrial toxicity which is associated with drug-induced phospholipidosis.
La présente invention concerne un procédé permettant de déterminer si un composé phospholipidotique risque d'entraîner une toxicité mitochondriale associée à une phospholipidose induite par des médicaments, le procédé consistant à a) mesurer le niveau de PAG dans un échantillon de fluide corporel, b) comparer le niveau de PAG déterminé avec le niveau de PAG d'un échantillon témoin, un niveau de PAG accru par rapport au niveau de l'échantillon témoin indiquant que ledit composé entraîne une toxicité mitochondriale associée à une phospholipidose induite par des médicaments.
Doessegger Lucette
Schlotterbeck Goetz
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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