Bioreductive conjugate for targeting a therapeutic agent

Details Bioreductive conjugate for targeting a therapeutic agent Bioreductive conjugate for targeting a therapeutic agent

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/573 (2006.01) A61K 45/00 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07J 5/00 (2006.01)

Patent

CA 2280874

The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.

L'invention concerne une méthode permettant de cibler un médicament vers des zones de tissu hypoxique et/ou ischémique situées dans le corps, dans laquelle l'espèce de médicament désirée est fixée à un excipient bioréducteur non cytotoxique. L'invention concerne également de nouveaux conjugués bioréducteurs, renfermant une fraction bioréductrice non cytotoxique à laquelle est fixé au moins un agent thérapeutique. Les composés de l'invention servent en particulier à traiter la polyarthrite rhumatoïde et d'autres états arthritiques, le diabète, l'athérosclérose, l'ictus, la septicémie, la maladie d'Alzheimer et d'autres troubles neurologiques, le cancer, la néphropathie, les maladies de l'appareil digestif, l'hépatopathie, la parodontite ou l'ischémie chroniques survenant après une greffe de tissu.

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