Bioremodelable prosthesis and methods of preparing and uses...

Details Bioremodelable prosthesis and methods of preparing and uses... Bioremodelable prosthesis and methods of preparing and uses...

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 2/18 (2006.01) A61L 27/24 (2006.01) A61L 27/36 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01) A61F 2/06 (2006.01) A61F 2/10 (2006.01) A61F 2/24 (2006.01) A61F 2/44 (2006.01)

Patent

CA 2217581

This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.

Cette invention concerne une prothèse qui, lorsqu'on l'implante sur un sujet mammalien, sert en tant qu'élément de remplacement fonctionnel d'une partie corporelle ou d'une structure tissulaire, et subit une biodégradation régulée, laquelle se produit en même temps qu'un remodelage biologique effectué par les cellules vivantes du sujet. On traite la prothèse de manière à la rendre non antigénique afin que celle-ci ne provoque pas une réponse immune humorale. La prothèse de l'invention possède, dans ses divers modes de réalisation, une double propriété dont la première est de fonctionner comme une partie corporelle de remplacement et la seconde est de servir de matrice de remodelage biologique destinée à l'interposition de cellules hôtes.

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