C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C07D 498/18 (2006.01) C12P 19/62 (2006.01)
Patent
CA 2567043
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with I module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9- deoxoprolylmeridamcyin and uses thereof.
L'invention concerne un complexe polykétide synthase composé d'une polykétide synthase à 15 modules totaux, d'une peptide synthase non ribosomique à un module et d'une cytochrome P450 hydroxylase. L'invention concerne également de nouvelles espèces Streptomyces, ainsi que des procédés permettant d'obtenir des Streptomyces modifiées. L'invention concerne encore de nouveaux composés, 36-cétoméridamycine, C9-désoxoméridamycine et C9-désoxoprolylméridamycine, ainsi que leurs utilisations.
Feng Xidong
Graziani Edmund
Haltli Bradley Arnold
He Min
Hucul John
Torys Llp
Wyeth
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