C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/275 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) C07C 317/50 (2006.01) C07C 323/60 (2006.01) C07C 323/62 (2006.01) C07D 213/75 (2006.01) C07D 295/185 (2006.01)
Patent
CA 2236773
Compounds of formula (I), or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
L'invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable de ceux-ci, qui inhibent la sécrétion des métalloprotéinases matricielles et de TNF.alpha. et sont utiles dans le traitement de pathologies inflammatoires. Elle porte aussi sur des compositions inhibant la sécrétion de métalloprotéinases matricielles et de TNF.alpha. et sur une méthode d'inhibition de la sécrétion de métalloprotéinases matricielles et de TNF.alpha..
Carrera George M. Jr.
Davidsen Steven K.
Fesik Stephen W.
Florjancic Alan
Holms James H.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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