Bis(biaryl) compounds as inhibitors of leukotriene biosynthesis

Details Bis(biaryl) compounds as inhibitors of leukotriene biosynthesis Bis(biaryl) compounds as inhibitors of leukotriene biosynthesis

C - Chemistry, Metallurgy

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C07D 405/00 (2006.01) A61K 31/33 (2006.01) C07D 217/04 (2006.01) C07D 217/22 (2006.01) C07D 311/16 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 407/04 (2006.01) C07D 409/14 (2006.01) C07D 413/02 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2169231

Compounds having the Formula I: Ar1Ar2-X-Ar3Ar4 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

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