Bisplatinum complexes active through the oral route

C - Chemistry – Metallurgy – 07 – F

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C07F 15/00 (2006.01) A61K 31/28 (2006.01)

Patent

CA 2393917

Compositions of formula (I), wherein X is halogen (chlorine, bromine, iodine); n, m = integer 2 to 8; p = 1, 2; A is selected from the group consisting of -B- , -B-(CH2)r-B-, -B-(CH2)r-B-(CH2)z-B-, with r and z ranging from 2-8; B is a group of formula -NR- wherein R is a group convertible into a hydrogen atom under physiological conditions, with the proviso that R is different from C1- C4 alkyl or acyl and from tert-butoxycarbonyl. Q-p is an anion selected from the group of chloride, bromide, iodide nitrate, sulfate, hydrogen sulfate and perchlorate.

L'invention concerne des compositions représentées par la formule (I), dans laquelle X est halogène (chlore, brome, iode); n, m = un nombre entier de 2 à 8; p = 1, 2; A est sélectionné dans le groupe comprenant -B-, -B-(CH¿2?)¿r?-B-, -B-(CH¿2?)¿r?-B-(CH¿2?)¿z?-B-, avec r et z compris entre 2 et 8; B est un groupe représenté par la formule -NR- dans laquelle R est un groupe pouvant être converti en atome d'hydrogène dans des conditions physiologiques, à condition que R soit différent d'alkyle ou acyle C¿1?-C¿4? et de tert-butoxycarbonyle; Q?-p¿ est un anion sélectionné dans le groupe composé de chlorure, de bromure, de nitrate d'iodure, de sulfate, de sulfate d'hydrogène et de perchlorate.

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