Bone cement and method of preparation

A - Human Necessities – 61 – L

Patent

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A61L 24/06 (2006.01) A61F 2/28 (2006.01) A61K 49/04 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) C08K 5/16 (2006.01) C08K 5/18 (2006.01) C08L 33/12 (2006.01)

Patent

CA 2284925

Orthopedic bone cements of low porosity, prepared by mixing together at least two liquid components under conditions that allow only minimal exposure to air, are disclosed. In a preferred system, each liquid component consists essentially of a solution of a linear (non-crosslinked) polymer or copolymer of methyl methacrylate (PMMA) dissolved in a non-crosslinking methyl methacrylate (MMA) monomer, with one such solution also containing an activator and a polymerization inhibitor and a second solution containing an initiator as well as a polymerization inhibitor. No reinforcing fillers are present, although a small amount (no more than 12 % by weight of the total cement composition) of a radiopacifier may be included in the composition. Since polymerization is initiated by mixing together two or more liquid solutions, and such mixing may be performed in a mixing chamber in which no air is required or is introduced during the mixing operation, prior problems of cement porosity and weakness resulting from air entrapment are avoided or greatly reduced while the reliability and reproducibility of the mixing operation are greatly improved.

L'invention porte sur des ciments osseux orthopédiques de faible porosité préparés en mélangeant ensemble au moins deux composants liquides dans des conditions permettant une exposition minimale à l'air. Dans le système préféré, chacun des composants liquides consiste principalement en une solution d'un polymère linéaire non réticulé ou d'un copolymère de métacrylate de méthyle (PMMA) dissout dans un métacrylate de méthyle (MMA) non réticulant, l'une de ces solutions contenant également un activateur et un inhibiteur de polymérisation et l'autre, un initiateur et également un inhibiteur de polymérisation. Il n'est pas prévu de charge de renforcement bien qu'une faible quantité (inférieure à 12 % du poids total de la composition de ciment) d'un opacificateur puisse être intégrée à la composition. Comme la polymérisation est amorcée lors du mélange de deux ou plus de deux solutions liquides, et que ce mélange peut se faire dans une chambre de mélange, ne nécessitant pas d'air, ou dans laquelle l'air est introduit pendant l'opération de mélangeage provenant des inclusions d'air, on évite ou réduit largement les problèmes antérieurs de porosité et d'affaiblissement du ciment, tandis que la fiabilité et la reproductibilité de l'opération de mélangeage sont notablement améliorées.

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