Bone sialoprotein collagen-binding peptides

Details Bone sialoprotein collagen-binding peptides Bone sialoprotein collagen-binding peptides

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 38/39 (2006.01) A61P 19/08 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2575416

The present invention provides Novel collagen-binding peptides of bone sialoprotein (BSP). Peptides comprising a portion of the N-terminal collagen binding domain of BSP (residues 1-100) are used to stimulate mineralization, nucleate hydroxyapatite, and promote bone formation in collagen expressing tissues. Medicaments for use in the same are also contemplated. Chimeric and conjugate peptides comprising said collagen-binding BSP peptides are also included.

L'invention se rapporte à des nouveaux peptides de liaison de collagène de sialoprotéine osseuse (BSP). Des peptides contenant une portion du domaine de liaison de collagène à N-terminal de BSP (résidus compris entre 1-100) servent à stimuler les minéralisation, l'hydroxyapatite nucléée, et à promouvoir la formation osseuse dans les tissus d'expression de collagène. L'invention se rapporte aussi à des médicaments associés. Elle concerne également des peptides chimériques et conjugués contenant ces peptides BSP à liaison de collagène.

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