C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/28 (2006.01) A61K 31/19 (2006.01) A61P 27/02 (2006.01) C07C 59/11 (2006.01) C07C 59/62 (2006.01) C07C 229/34 (2006.01) C07C 233/47 (2006.01) C07C 271/22 (2006.01)
Patent
CA 2361647
The present invention is directed to a method for the prophylactic and therapeutic treatment of diabetic retinopathy. The method involves the administration of an inhibitor of formulae (I), (II) and (III) of the branch chain amino acid-dependent aminotransferase (BCAT) pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the retina for diabetic retinopathy prophylactically or therapeutically. The present invention is also directed to several novel inhibitors of formula (IV) of the BCAT pathway. In formulae (I-IV), n, m, X and R1-R13 have the meanings given in the description.
La présente invention concerne un procédé de traitement prophylactique et thérapeutique de la rétinopathie diabétique. Le procédé comprend l'administration à un animal, à un mammifère par exemple, en particulier à un être humain, d'un inhibiteur, de formules (I), (II) et (III), du passage de l'aminotransférase acides aminés-dépendante à chaîne ramifiée (branch chain amino acid-dependent aminotransferase / BCAT) en quantité suffisante pour traiter de manière prophylactique ou thérapeutique la rétine en cas de rétinopathie diabétique. Cette invention concerne également différents nouveaux inhibiteurs, de formule IV, du passage de la BCAT. Dans les formules (I-IV), n, m, X et R¿1?-R¿13? correspondent aux éléments indiqués dans la description.
Bryans Justin Stephen
Hu Lain-Yen
Hutson Susan M.
Lanoue Kathryn Foley
Lieth Erich
Macrae & Co.
The Penn State Research Foundation
Wake Forest University
Warner-Lambert Company
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