Buccal, polar and non-polar spray or capsule containing...

A - Human Necessities – 61 – K

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Details

A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 9/72 (2006.01) A61K 31/00 (2006.01) A61K 47/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2497268

Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II: aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.

Selon cette invention, on a mis au point des capsules ou des vaporisateurs aérosols buccaux faisant appel à un solvant polaire et non polaire qui délivrent des composés biologiquement actifs pour une absorption rapide par la muqueuse orale, ce qui permet d'obtenir un déclenchement rapide de leur effet. Les compositions polaires buccales de cette invention sont représentées par : la formulation I qui contient un solvant polaire aqueux, un composé actif et un agent aromatisant facultatif ; la formulation II qui contient un solvant polaire aqueux, un composé actif, un agent aromatisant facultatif et un propulseur ; la formulation III qui contient un solvant non polaire, un composé actif et un agent aromatisant facultatif ; et la formulation IV qui contient un solvant non polaire, un composé actif, un agent aromatisant facultatif et un propulseur.

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