C-5 modified indazolylpyrrolotriazines

Details C-5 modified indazolylpyrrolotriazines C-5 modified indazolylpyrrolotriazines

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2467068

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

L'invention concerne des composés représentés par la formule (I) et des sels de ceux-ci pharmaceutiquement acceptables. Ces composés de formule (I) inhibent l'activité de la tyrosine kinase de récepteurs du facteur de croissances tels que HER1, HER2 et HER4, ce qui rend ces derniers utiles en tant qu'agents antiproliférants. Ces composés de formule (I) sont également utiles dans le traitement d'autres maladies associées à des chemins de transduction de signal à travers des récepteurs du facteur de croissance.

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