[c]-fused bicyclic proline derivatives and their use for...

Details [c]-fused bicyclic proline derivatives and their use for... [c]-fused bicyclic proline derivatives and their use for...

C - Chemistry, Metallurgy

07

D

C07D 209/44 (2006.01) A61K 31/4035 (2006.01) A61P 19/02 (2006.01) C07D 209/94 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 419/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2521364

This invention relates to a compound which is [c]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [c]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [c]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

L'invention concerne un composé qui est un dérivé de proline bicyclique ?c?-condensé, ou bien son sel pharmaceutiquement acceptable ; elle concerne également une composition pharmaceutique renfermant ce composé ou son sel, ainsi que des méthodes pour traiter des maladies, notamment, mais non exclusivement, des méthodes pour la prévention ou l'inhibition de lésions du cartilage articulaire et la prévention ou le traitement de maladies caractérisées par des lésions du cartilage articulaire, une inflammation articulaire, ou bien une arthralgie. Ces dérivés de proline sont des composés de la formule (I) décrite ci-dessus. Parmi les maladies caractérisées par des lésions du cartilage articulaire ou des arthralgies, on peut citer par exemple l'arthrose ou la polyarthrite rhumatoïde. Cette dernière se caractérise également par une inflammation articulaire. L'invention concerne par ailleurs des méthodes pour synthétiser et préparer les dérivés de proline bicycliques ?c?-condensés, ou bien leur sel pharmaceutiquement acceptable.

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