C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/10 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 37/04 (2006.01) C07H 7/02 (2006.01) C07H 17/04 (2006.01)
Patent
CA 2653647
The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
La présente invention concerne de nouveaux C-glycolipides synthétiques qui induisent sélectivement une réponse immune de type Th1, caractérisée par une sécrétion accrue de IL-12 et une activation accrue des cellules dendritiques. Les composés selon l'invention sont de ce fait utiles pour traiter des infections, des cancers, des troubles liés à la prolifération cellulaire et des maladies auto-immunes, à la fois directement et comme adjuvants.
Chen Guangwu
Franck Richard
Tsuji Moriya
Yang Guangli
New York University
Research Foundation Of The City University Of New York
Robic
The Aaron Diamond Aids Research Center For The City Of New York Inc.
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