C-glycoside derivatives or salts thereof for use as...

Details C-glycoside derivatives or salts thereof for use as... C-glycoside derivatives or salts thereof for use as...

C - Chemistry, Metallurgy

07

D

C07D 309/10 (2006.01) A61K 31/351 (2006.01) A61K 31/381 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/4433 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 405/04 (2006.01) C07D 405/10 (2006.01) C07D 407/04 (2006.01) C07D 407/10 (2006.01) C07D 409/04 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 49

Patent

CA 2526145

The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via -X- and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

L'invention concerne un dérivé de C-glycoside de formule générale (I), ou son sel. Il s'agit d'un composé utile comme inhibiteur de cotransport de Na<+>-glucose dans un médicament, par exemple, contre le diabète, et en particulier le diabète de type 2 et le diabète de type 1, et aussi dans un médicament contre les maladies à résistance insulinique et différentes maladies liées au diabète, y compris l'obésité. Dans ce composé, la chaîne B est liée à la chaîne A via -X-, et la chaîne A est liée directement à un résidu sucre.

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