C-jun phosphorylation inhibitors

Details C-jun phosphorylation inhibitors C-jun phosphorylation inhibitors

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2480671

BMAL1, BPL1, KIAA1491 complete (SEQ ID NO:1) and KIAA0596CT (SEQ ID NO:2) having a function of interacting with c-Jun N-terminal kinase 3 are found out. Using them and peptides originating therein, drugs and medicinal compositions to be used in inhibiting the phosphorylation of c-Jun, inhibiting the functions (for example, transcription activation) of c-Jun, inhibiting apoptosis (for example, apoptosis in nerve cells) and preventing and/or treating neurodegenerative diseases (for example, polyglutamine disease and Alzheimer~s disease) and a method therefor are provided.

La présente invention a pour objet BMAL1, BPL1, KIAA1491 complète (SEQ ID NO:1) et KIAA0596CT (SEQ ID NO:2) qui ont une fonction d'interaction avec la kinase 3 N-terminale c-Jun. L'invention concerne également leur utilisation ou l'utilisation de peptides qu'ils permettent d'obtenir, de médicaments ou de compositions pharmaceutiques pour inhiber la phosphorylation de c-Jun, inhiber les fonctions (par exemple la transcription ou l'activation) de c-Jun, inhiber l'apoptose (par exemple l'apoptose des cellules nerveuses), et prévenir et/ou traiter les maladies de neurodégénérescence (par exemple la maladie de la polyglutamine et la maladie d'Alzheimer). L'invention concerne aussi un procédé correspondant.

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