C-terminal amidating enzyme composition, process for...

C - Chemistry – Metallurgy – 12 – N

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195/38, 195/39.1

C12N 9/02 (2006.01) C07K 1/107 (2006.01) C12P 21/00 (2006.01)

Patent

CA 1338415

A C-terminal amidating enzyme composition derived from serum or plasma which acts on a C-terminal glycine adduct represented by the following formula: Image (I) (wherein A represents a residue other than .alpha.-carboxyl group and an .alpha.-amino group or imino group derived from naturally occurring .alpha.-amino acid, X represents hydrogen atom or a residue of an amino acid derivative which is bonded to N atom through carbonyl group) to participate in the reaction for forming a C-terminal amidated product represented by the following formula: Image (II) (wherein A and X have the same meanings as above) and glyoxylic acid, a process for preparing the same, and a method of utilizing the same.

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