C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/18 (2006.01) A61K 31/165 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) C07C 233/32 (2006.01) C07C 259/06 (2006.01) C07D 207/335 (2006.01) C07D 207/337 (2006.01) C07D 209/14 (2006.01) C07D 213/50 (2006.01) C07D 213/56 (2006.01) C07D 235/14 (2006.01) C07D 235/16 (2006.01) C07D 263/32 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2277105
C-terminal compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
Cette invention concerne des composés à terminaison C qui correspondent à la formule (I). Ces composés consistent en de puissants inhibiteurs de métalloprotéinase matricielle, et peuvent être utilisés dans le traitement de maladies où la métalloprotéinase matricielle joue un rôle. Cette invention concerne également des compositions inhibant la métalloprotéinase matricielle, ainsi qu'un procédé d'inhibition de métalloprotéinase matricielle chez un mammifère.
Curtin Michael L.
Davidsen Steven K.
Florjancic Alan Scott
Giesler Jamie R.
Guo Yan
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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