C-terminal modified...

Details C-terminal modified... C-terminal modified...

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/06 (2006.01) A61P 9/10 (2006.01) A61P 37/02 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2365341

This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.

L'invention concerne de nouveaux composés (à substitution N) indoles inhibiteurs de ICE/ced-3. L'invention concerne également des compositions pharmaceutiques de ces composés indoles, ainsi que l'utilisation de ces compositions dans le traitement de patients atteints de maladies inflammatoires, autoimmunes et neurodégénératives, et dans la prévention d'accident ischémiques.

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