C-terminal modified oxamyl dipeptides as inhibitors of the...

Details C-terminal modified oxamyl dipeptides as inhibitors of the... C-terminal modified oxamyl dipeptides as inhibitors of the...

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/06 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07C 237/22 (2006.01) C07C 317/50 (2006.01) C07D 295/135 (2006.01) C07D 295/185 (2006.01) C07F 9/32 (2006.01)

Patent

CA 2433879

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Cette invention concerne de nouveaux composés inhibiteurs oxamylpeptidiques de la famille ICE/ced-3 des cistéines protéases . L'invention concerne également des compositions pharmaceutiques renfermant ces composés ainsi que leur utilisation pour le traitement de maladies inflammatoires, auto-immunes et neurodégénératives, pour la prévention de lésions ischémiques, et pour la conservation d'organes destinés à une transplantation.

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