C3 binding protein of streptococcus pneumoniae

Details C3 binding protein of streptococcus pneumoniae C3 binding protein of streptococcus pneumoniae

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/09 (2006.01) A61K 39/40 (2006.01) C07K 14/315 (2006.01) C07K 14/74 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2269636

This invention relates to the identification of a human complement C3 binding protein from Streptococcus pneumoniae and to its sequence and to methods for its purification and use. The protein binds but does not degrade or cleave C3 and is implicated in S. pneumoniae virulence. The protein is recognized by antibodies produced by humans recovering from pneumococcal infection.

La présente invention concerne l'identification d'une protéine de liaison C3 à complément humain de Streptococcus pneumoniae, sa séquence et les procédés de purification et d'utilisation. La protéine se lie mais ne dégrade ni ne clive C3 et est impliquée dans le mécanisme de virulence de S. pneumonia. La protéine est reconnue par des anticorps produits lors de la guérison d'humains ayant contracté une infection à pneumocoques.

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