Cadmium containing compositions

Details Cadmium containing compositions Cadmium containing compositions

A - Human Necessities

61

K

A61K 33/24 (2006.01) A61K 38/55 (2006.01)

Patent

CA 2377920

Methods and compositions are provided for decreasing or regulating ratios of zinc:cadmium and PGE2:PGF2.alpha. and regulating the concentration of zinc- containing and PGE2-dependent matrix metalloproteinases in body fluids and tissues of a mammal, comprising administering to the mammal an amount of a pharmaceutically acceptable and bioavailable cadmium salt. Elevated or fluctuating levels of PGE2 and zinc and elevated concentrations of zinc- containing and PGE2-dependent matrix metalloproteinases have been found to be associated with the development of certain diseases.

L'invention concerne des méthodes et des compositions destinées à réduire ou à réguler les coefficients de zinc:cadmium et de PGE2:PGF2alpha, et à réguler la concentration de métalloprotéinases matricielles contenant du zinc et dépendantes de PGE2 dans les liquides et tissus organiques d'un mammifère, en administrant au mammifère une quantité de sel de cadmium acceptable d'un point de vue pharmaceutique et biodisponible. On a découvert que des niveaux élevés ou fluctuants de PGE2 et de zinc, ainsi que des concentrations élevées de métalloprotéinases matricielles contenant du zinc et dépendantes de PGE2, sont associés au développement de certaines maladies.

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