Cads as modifiers of the p53 pathway and methods of use

Details Cads as modifiers of the p53 pathway and methods of use Cads as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) C07H 21/04 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449206

Human CAD genes are identified as modulators of the P53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CAD are provided.

Des gènes humains de cadhérine sont identifiés en tant que modulateurs de la voie p53, et constituent donc des cibles thérapeutiques pour des troubles associés à une fonction déficiente de p53. L'invention concerne également des procédés d'identification de modulateurs de p53, comprenant le criblage pour obtenir des agents modulateurs de l'activité des cadhérines.

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