C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/56 (2006.01) G01N 33/96 (2006.01)
Patent
CA 2162432
The invention relates to a plasma which can be used as a calibrator in coagulation tests which detect the degradation of factor V by activated protein C (APC), to the preparation of such a plasma and to its use. The problem with calibrators in current coagulation tests is the requirement for a reference concentration calibrator for APC-resistant factor V in activated protein C time tests. The calibrator of the present invention solves this problem as it provides a plasma composition with beneficial qualities such as shortened clotting time in an activated protein C time test. The calibrator of the present invention contains human plasma diluted with non-human animal plasma, or factor V-containing fractions of non-human plasma. The non-human animal factor V in the calibrator of the present invention cannot be cleaved by human activated protein C, and retains markedly high factor V activity, thus reducing the APCT.
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Siemens Healthcare Diagnostics Products Gmbh
LandOfFree
Calibrator for use in test methods for detecting a defective... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Calibrator for use in test methods for detecting a defective..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calibrator for use in test methods for detecting a defective... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1689384