Camptothecins with a modified lactone ring

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 491/22 (2006.01) A61K 31/47 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 307/00 (2006.01) C07D 313/00 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2485201

Compounds of formula (I) or (II) are described: where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.

La présente invention concerne des composés de formule (I) ou (II) où les groupes sont tels que définis dans la description, les mélanges racémiques, leurs énantiomères individuels, leurs diastéréoisomères individuels, leurs mélanges et leurs sels pharmaceutiquement acceptables. Lesdits composés sont des inhibiteurs de la topoisomérase I.

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