Cancer associated plexinb1 mutations

Details Cancer associated plexinb1 mutations Cancer associated plexinb1 mutations

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2507761

The present inventors have identified cancer associated mutations in plexinB1, which is a transmembrane receptor that mediates semaphorin signalling. The frequency of plexinB1 mutations, in particular in prostate and breast cancer, indicates that plexinB1 may be useful in the screening and diagnosis of cancer and as a drug target in the development of anti-cancer therapeutics.

Les présents inventeurs ont identifié des mutations associées au cancer dans la plexine B1, un récepteur transmembranaire médiant la signalisation de la sémaphorine. La fréquence des mutations de la plexine B1, en particulier dans les cancers de la prostate et du sein, indique que la plexine B1 peut être utile dans le dépistage et le diagnostic du cancer et en tant que cible médicamenteuse dans le développement de thérapeutiques anticancéreuses.

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