A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/20 (2006.01) A61P 35/00 (2006.01) C07K 16/32 (2006.01)
Patent
CA 2408974
Methods for treating a subject with a cancer that is characterized by overexpression of HER2 receptor protein using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-HER2 antibody or fragment thereof are provided. These anti-tumor agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), the other containing at least one anti-HER2 antibody (or fragment thereof), according to a dosing regimen. Administering of these two agents together potentiates the effectiveness of the anti-HER2 antibody alone, resulting in a positive therapeutic response that is improved with respect to that observed with this anti-tumor agent.
La présente invention concerne des procédés de traitement d'un sujet atteint d'un cancer se caractérisant par la surexpression de la protéine de récepteur HER2, au moyen d'une combinaison d'interleukine 2 (IL-2) ou d'une de ses variantes, et d'au moins un anticorps anti-HER2 ou fragment de celui-ci. Ces agents anti-tumoraux sont administrés sous forme de deux compositions pharmaceutiques séparées, l'une contenant l'interleukine 2 (IL-2) (ou variante), l'autre contenant au moins un anticorps anti-HER2 (ou fragment), selon une posologie donnée. L'administration de ces deux agents permet de renforcer l'efficacité de l'anticorps anti-HER2 seul, ce qui permet d'obtenir une réponse thérapeutique positive qui est supérieure à celle observée avec cet agent anti-tumoral.
Caligiuri Michael A.
Meropol Neal J.
Schilsky Richard L.
Arch Development Corporation
Borden Ladner Gervais Llp
Health Research Inc.
LandOfFree
Cancer treatments by using a combination of an antibody... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cancer treatments by using a combination of an antibody..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cancer treatments by using a combination of an antibody... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1349593