C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 333/16 (2006.01) C07C 33/12 (2006.01) C07C 43/178 (2006.01) C07C 405/00 (2006.01) C07D 307/42 (2006.01) C07D 309/12 (2006.01) C07D 317/72 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1223582
ABSTRACT OF THE DISCLOSURE The invention provides compounds of the general formula Image (I), in which X is oxygen or -CH2-; A is CH2-CH2; trans-CH=CH- or -C?C- , W is -CH(OR); -D-E-R2 has the structure Image wherein Y2 and Y3 are independently each H or C1-4-alkyl and Image represents Image Image Image or Image wherein Y4 is C1-5-alkyl; and Y5 is H or C1-5- alkyl and is different from R2;,R1 is OR; R2 is H, C1-10-alkyl, C2-10-alkenyl; C1-10-alkyl or C2-10-alkenyl, each substituted by C6-10-aryl or substituted C6-10-aryl as defined below; C4-10- cycloalkyl; C4-10-cycloalkyl substituted by C1-4-alkyl, C6-10- aryl, C6-10-aryl substituted by 1 to 3 halogen atom, a phenyl group, 1 to 3 alkyl groups each of 1 to 4 carbon atoms, or a chloromethyl, fluoromethyl, trifluoromethyl, carboxyl, C1-C4- alkoxy or hydroxy group; or an aromatic heterocycle or 5 or 6 ring atoms, one of which is O, N or S, the remainder being carbon atoms; and R is H or tetrahydropyranyl, tetrahydrofuranyl, .alpha.- ethoxyethyl, trimethylsilyl, dimethyl-tert-butylsilyl, tribenzyl- silyl, C1-4-alkanoyl, benzoyl or an acyl group of a C1-15-hydro- carbon sulfonic acid. The compounds have hyptotensive and bron- chodilative properties. Furthermore, they can be used for the prophylaxis and therapy of cardiac infarct and for the treatment of stroke. They may be prepared by reducing the corresponding 1- carboxylic acid derivatives.
403276
Casals-Stenzel Jorge
Mannesmann Gerda
Nieuweboer Bob
Raduchel Bernd
Schillinger Ekkehard
Marks & Clerk
Schering Aktiengesellschaft
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