Carbacyclins, processes for their manufacture and their use...

Details Carbacyclins, processes for their manufacture and their use... Carbacyclins, processes for their manufacture and their use...

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 309/12 (2006.01) C07C 405/00 (2006.01)

Patent

CA 1251200

ABSTRACT "Novel carbacyclins, process for their manufacture and their use as medicaments" Novel (5E)-13,14,18,18,19,19-hexadehydro-3-oxa- 6a-carbaprostaglandin-I2 derivatives of the general formula I Image (I) (in which R1, R2, R3 and R4 each represents H or C1-C5- alkyl and R5 represents C1-C5-alkyl) and physiologically tolerable salts thereof with bases, and the manufacture of such compounds. The compounds of the general formula I and salts thereof have inter alia a hypotensive action and may accordingly be made up into pharmaceutical preparations with suitable carriers.

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