C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/03 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/277 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/426 (2006.01) A61P 35/00 (2006.01) C07C 233/05 (2006.01) C07C 233/08 (2006.01) C07C 233/09 (2006.01) C07D 207/40 (2006.01) C07D 209/14 (2006.01) C07D 213/06 (2006.01) C07D 235/24 (2006.01) C07D 307/34 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01)
Patent
CA 2423868
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (see above formula) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR1C (=O) - and -C (=O) NR1-; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, and ethers, thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and to inhibit conditions such as cancer and psoriasis.
L'invention concerne certains composés d'acide carbamique actifs inhibant l'activité HDAC et correspondant à la formule (1), dans laquelle A désigne un groupe aryle ; Q?1¿ désigne un groupe leader aryle ayant un squelette d'au moins 2 atomes de carbone; J désigne un enchaînement amide choisi à partir de: -NR?1¿C(=O)- et-C(=O)NR?1¿-; R?1¿ désigne un substituant amido; et Q?2¿ désigne un groupe leader acide ; ainsi que les sels, solvates, amides, esters, éthers pharmaceutiquement acceptables, les formes protégés chimiquement et les promédicaments de ces composés. L'invention concerne en outre des compositions pharmaceutiques comprenant de tels composés, ainsi que l'utilisation de ces composés et de ces compositions, à la fois in vitro et in vivo, en vue d'inhiber HDAC et d'inhiber, par exemple, des états de proliférations tels que cancers et psoriasis.
Amolins Andris
Andrianov Victor
Bokaldere Rasma Melita
Dikovska Klara
Duffy James E. S.
Prolifix Limited
Smart & Biggar
Topotarget Uk Limited
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