Carbamoyl tetrahydropyridine derivatives

Details Carbamoyl tetrahydropyridine derivatives Carbamoyl tetrahydropyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) C07D 211/78 (2006.01) C07D 473/34 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2366642

Carbamoyl tetrahydropyridine derivatives represented by general formula (1) and being efficacious against CRF-related diseases; medicinally acceptable salts of the same; and intermediates for the preparation thereof, wherein R1 and R2 are each independently hydrogen, C1-C5 alkyl, or the like; Y1-Y2 is (R4)C=C(R5), (R6)C=N, N=N, (R7)N-CO, or N=C(R8); X1, X2 and X3 are each independently hydrogen, halogeno, or the like; R3, R4, R5 and R6 are each independently hydrogen or alkyl; R7 is hydrogen, C1-C5 alkyl, or the like; and R8 is hydrogen or carbamoyl.

L'invention concerne des dérivés de carbamoyltetrahydropyridine efficaces contre les maladies associées à la corticolibérine, ainsi que leurs sels médicalement acceptables, et des produits intermédiaires pour leur préparation. Les dérivés de l'invention sont représentés par la formule générale (1), dans laquelle R?1¿ et R?2¿ sont indépendamment un hydrogène, un groupe alkyle en C¿1?-C¿5? ou analogue; Y?1¿-Y?2¿ représente un groupe (R?4¿)C=C(R?5¿), (R?6¿)C=N, N=N, (R?7¿)N-CO ou N=C(R?8¿); X?1¿, X?2¿ et X?3¿ sont indépendamment un hydrogène, halogéno, ou analogue; R?3¿, R?4¿, R?5¿ et R?6¿ sont indépendamment un hydrogène ou un groupe alkyle; R?7¿ représente un hydrogène, un groupe alkyle en C¿1?-C¿5? ou analogue; et R?8¿ représente un hydrogène ou un groupe carbamoyle.

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