Carbapenem derivatives

Details Carbapenem derivatives Carbapenem derivatives

C - Chemistry, Metallurgy

07

D

260/271, 260/299

C07D 477/00 (2006.01) C07D 477/20 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2002551

Carbapenem derivatives of formula (I): (see fig. I) wherein (a) R1 is a hydrogen atom, an alkyl group of from 1 to 6 carbon atomsr a hydroxy-lower alkyl group or a protected hydroxy-lower alkyl group of from 1 to 6 carbon atoms in its alkyl moiety, (b) COOR2 is a carboxyl group, a carboxylate anion or a protected carboxyl group, (c) R3 is an alkyl group of from 1 to 6 carbon atoms and (d) R4 is a substituted or unsubstituted heterobicyclic group of formula (II): (see fig. II) in which the partial structure (see fig. III) is a 5- or 6-membered, saturated or unsaturated, nitrogen-containing heterocycle containing 1 to 4 hetero atoms each selected from the group consisting of oxygen, sulfur and nitrogen, at least one hetero atom being nitrogen, and is which R5 and R6 each is a hydrogen atom or an appropriate substituent, any isomeric form thereof, and pharmacologically acceptable salts thereof are potent and stable antimicrobial agents.

Dérivés de carbapénème de formule I (voir fig. I), où : a) R1 est un atome d'hydrogène, un groupe alkyle de 1 à 6 atomes de carbone, un groupe hydroxy-alkyle inférieur ou un groupe hydroxy-alkyle inférieur protégé de 1 à 6 atomes de carbone dans la fraction alkyle; b) COOR2 est un groupe carboxyle, un anion carboxylate ou un groupe carboxyle protégé; c) R3 est un groupe alkyle de 1 à 6 atomes de carbone; d) R4 est un groupe hétérobicyclique, avec ou sans substitution, de formule II (voir fig. II), dont la structure partielle (voir fig. III) est un hétérocycle azoté de 5 ou 6 chaînons, saturé ou non, renfermant 1 à 4 hétéroatomes, choisis chacun parmi un oxygène, un soufre et un azote, au moins un hétéroatome étant de l'azote; R5 et R6 sont chacun un atome d'hydrogène ou un substituant approprié. Toute forme isomère de ces dérivés et leurs sels pharmacocompatibles sont des agents antimicrobiens stables et puissants.

Affiliated with

Also associated with

Rating

Carbapenem derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carbapenem derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbapenem derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1950625