C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/88 (2006.01) C07D 209/94 (2006.01) C07D 213/82 (2006.01) C07D 239/42 (2006.01) C07D 261/14 (2006.01) C07D 263/32 (2006.01) C07D 271/10 (2006.01) C07D 285/06 (2006.01) C07D 307/68 (2006.01) C07D 307/84 (2006.01) C07D 317/66 (2006.01) C07D 333/38 (2006.01) C07D 487/22 (2006.01) C07D 495/04 (2006.01) C07D 498/22 (2006.01)
Patent
CA 2588607
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds and compositions useful in the inhibition of BEGF production, and/or in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Conformément à l'invention, des composés qui inhibent l'expression de VEGF de manière post-transcriptionnelle ont été identifiés, et des procédés permettant leur utilisation sont proposés. L'invention concerne, suivant un aspect, des composés et des compositions utilisés dans l'inhibition de la production de VEGF, et/ou dans l'inhibition de l'angiogenèse, et/ou dans le traitement du cancer, de la rétinopathie diabétique ou de la dégénérescence maculaire exudative. Suivant un autre aspect, l'invention concerne des procédés d'inhibition de la production de VEGF, l'inhibition de l'angiogenèse, et/ou le traitement du cancer, de la rétinopathie diabétique ou de la dégénérescence maculaire exudative au moyen des composés de l'invention.
Cao Liangxian
Choi Soongyu
Hwang Seongwoo
Lennox William Joseph
Moon Young-Choon
Mbm Intellectual Property Law Llp
Ptc Therapeutics Inc.
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