Carbostyril compound

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/06 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/473 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 17/16 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2580811

The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

La présente invention a pour objet un dérivé de carbostyrile de Formule Générale (1), ou un sel dudit dérivé, où A est une liaison directe, un groupement alkylène court, ou un groupement alkylidène court ; X est un atome d~oxygène ou de soufre ; R4 et R5 représentent chacun un atome d~hydrogène ; la liaison entre les positions 3 et 4 du squelette carbostyrile peut être simple ou double ; R1 est un atome d~hydrogène ou un groupement similaire ; R2 est un atome d~hydrogène ou un groupement similaire ; et R3 est un atome d~hydrogène ou un groupement similaire. Ledit dérivé de carbostyrile, ou un sel dudit dérivé, induit la production de protéines TFF, et peut donc être employé dans le traitement prophylactique ou thérapeutique de troubles tels que les maladies du tube digestif, les maladies buccales, les maladies des voies respiratoires supérieures, les maladies des voies respiratoires, les maladies de l~oeil, les cancers, et les plaies.

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