Carbostyril derivatives

Details Carbostyril derivatives Carbostyril derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 215/227 (2006.01)

Patent

CA 2047307

ABSTRACT OF THE DISCLOSURE Carbostyril derivatives of Formula I: Image ( I ) wherein: m is 0, 1, or 2; n is 0, 1, or 2; R1 is hydrogen or lower alkyl; R2 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, aralkoxy, or acyloxy; R3 is hydrogen, halogen, lower alkyl, or lower alkoxy; R4 is hydrogen, hydroxy, lower alkyl, or acyloxy, provided that when R4 is hydroxy or acyloxy, m and n are both 1; R5 is hydrogen or lower alkyl; and R6 is alkyl, hydroxyalkyl, alkoxyalkyl, or (dialkylamino)alkyl; and the pharmaceutically acceptable acid addition salts and N-oxides (at the carbostyril nitrogen) thereof, and compositions containing them, are useful in treating cardiovascular diseases, particularly arrhythmias. Methods of preparing intermediates, the compounds, their formulations and methods of treatment therewith are also disclosed. YPCSA008 27060-FF

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