Carboxamide compounds and their use as chemokine receptor...

Details Carboxamide compounds and their use as chemokine receptor... Carboxamide compounds and their use as chemokine receptor...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2708364

Chemokine receptor antagonists, in particular, compounds of Formula (I- A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

La présente invention concerne des antagonistes du récepteur des chimiokines, notamment, des composés de formule (I-A) qui agissent comme antagonistes du récepteur CCR2 des chimiokines, y compris des compositions pharmaceutiques et leurs utilisations pour le traitement et la prévention de maladies associées à l'accumulation de monocytes, l'accumulation de lymphocytes ou l'accumulation de leucocytes.

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