Carboxy terminal il-6 muteins

Details Carboxy terminal il-6 muteins Carboxy terminal il-6 muteins

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) C07K 14/54 (2006.01) C12N 1/21 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2140132

2140132 9402512 PCTABS00030 This invention relates to a Carboxy Terminal IL-6 Mutein with enhanced biological activity. The invention comprises a mutein of IL-6 having increased activity wherein the mutein has an amino acid substitution at, or corresponding to, amino acid location 171 or 175 of IL-6 having the wild-type sequence.

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