Carboxylic acid derivative and salt thereof

Details Carboxylic acid derivative and salt thereof Carboxylic acid derivative and salt thereof

C - Chemistry, Metallurgy

07

C

C07C 59/64 (2006.01) A61K 31/192 (2006.01) A61K 31/27 (2006.01) A61K 31/357 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/4704 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/18 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07C 59/

Patent

CA 2442319

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. (see formula I) Wherein R1 represents a hydrogen atom, hydroxyl group, halogen, carboxyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents; L represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; M represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; T represents a single bond, or a C1-3 alkylene group, a C2-3 alkenylene group or a C2-3 alkynylene group, each of which may have one or more substituents; W represents a carboxyl group; represents a single bond etc. ; X represents a single bond, oxygen atom, a group represented by -NR X1CQ1O- (wherein Q1 represents an oxygen atom or sulfur atom; and R X1 represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents) ,-OCQ1NR X1- (wherein Q1 and R X1 are as defined above), -CQ1NR X1O- (wherein Q1 and R X1 are as defined above) , ONR X1CQ1- (wherein Q1 and R X1 are as defined above) , -Q2SO2- (wherein Q2 is an oxygen atom or -NR X10- (wherein R X10 represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc. , each of which may have one or more substituents) ) or -SO2Q2- (wherein Q2 is as defined above), (wherein, provided that R X2 and R X3, and/or R X4 and R X5 may together form a ring, Q3 and Q4 are the same as or different from each other and each represents an oxygen atom, (O)S(O) or NR X10 (wherein NR X10 is as defined above)); Y represents a 5- to 14-membered aromatic group etc., which may have one or more substituents and one or more hetero atoms; and the ring Z represents a 5-- to 14-membered aromatic group which may have 0 to 4 substituents and one or more hetero atoms, and wherein part of the ring may be saturated.

La présente invention concerne un médicament contenant en tant que principe actif un nouveau dérivé de l'acide carboxylique utile comme agent d'amélioration de la résistance à l'insuline. Le dérivé de l'acide carboxylique correspond à la formule générale (I) dans laquelle: R?1¿ représente carboxyle, alcoyle, alcoxy; L et T représentent chacun une liaison simple, alcoylène, alkynylène; M représente alcoylène; W représente carboxyle; X représente oxygène, -NR?x1¿CQ?1¿O-, -OCQ?1¿NR?x1¿-, -CQ?1¿NR?x1¿O-(où Q?1¿ représente oxygène; et R?x1 ¿représente hydrogène, alcoyle); et Y et Z représentent chacun un groupe aromatique de 5 à 14 chaînons éventuellement substitué). L'invention concerne également un sel ou un ester du dérivé et un hydrate de l'un de ceux-ci.

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