C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/51 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/22 (2006.01) A61K 31/222 (2006.01) A61K 31/235 (2006.01) A61K 31/27 (2006.01) A61K 31/277 (2006.01) A61K 31/40 (2006.01) A61K 31/505 (2006.01) A61K 38/00 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07C 229/22 (2006.01) C07C 229/36 (2006.01) C07C 233/22 (2006.01) C07C 233/47 (2006.01) C07C 233/83 (2006.01) C07C 233/87 (2006.01) C07C 235/12 (2006.01) C07C 235/34 (2006.01) C07C 235/52 (2006.01) C07C 235/60 (2006.01) C07C 235/66
Patent
CA 2382757
Substances inhibiting cell adhesion mediated by adhesion molecules (in particular, VLA-4) which enable the prevention and treatment of inflammatory diseases caused by leukocyte (for example, monocyte, lymphocyte or eosinocyte) infiltration. A group of carboxylic acid derivatives exemplified by a compound represented by the formula (140) and adhesion molecule inhibitors containing the same as the active ingredient
L'invention porte sur des substances inhibitrices de l'adhésion cellulaire médiée par des molécules d'adhésion (particulièrement la VLA-4) et permettant de prévenir et traiter les maladies inflammatoires dues à des infiltrations de leucocytes (par exemple des monocytes, des lymphocytes ou des éosinocytes). L'invention porte également sur un groupe de dérivés de l'acide carboxylique représenté par un composé de la formule suivante (140), et sur des inhibiteurs de l'adhésion moléculaire dont il est le principe actif.
Funahashi Miyuki
Ishigaki Takeshi
Kainoh Mie
Kaneko Masayuki
Takahashi Toshiya
Smart & Biggar
Toray Industries Inc.
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