C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/4704 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 207/416 (2006.01) C07D 211/86 (2006.01) C07D 213/02 (2006.01) C07D 213/62 (2006.01) C07D 213/69 (2006.01) C07D 213/72 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 221/04 (2006.01) C07D 237/16 (2006.01) C07D 237/22 (2006.01) C07D 239/28 (2006.01) C07D 239/46 (2006.01) C07D 239/47 (2006.01) C07D 317
Patent
CA 2366800
A method for the inhibition of the binding of .alpha.4.beta.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which .alpha.4.beta.1 is involved.
Méthode pour l'inhibition de la liaison de l'alpha-4-bêta-1-intégrine à ses récepteurs, par exemple la MACV-1 (molécule-1 d'adhésion aux cellules vasculaires) et la fibronectine; des composés inhibant cette liaison; compositions pharmaceutiquement actives renfermant de tels composés; l'utilisation de tels composés soit dans ce qui précède, soit dans des formulations pour la lutte contre les maladies mettant en jeu l'alpha-4-bêta-1, et pour la prévention de telles maladies.
Biediger Ronald J.
Chen Qi
Decker Radford E.
Holland George W.
Kassir Jamal M.
Encysive Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Texas Biotechnology Corporation
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