Cardiac diseases improving agents

Details Cardiac diseases improving agents Cardiac diseases improving agents

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/33 (2006.01) A61K 31/40 (2006.01) A61K 45/00 (2006.01) C07D 207/16 (2006.01) C07D 213/79 (2006.01) C07D 257/04 (2006.01) C07D 295/192 (2006.01)

Patent

CA 2224910

This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly, this invention relates to cardiac diseases improving agents composed of effective ingredients of aromatic compounds or pharmacologically acceptable salts thereof shown by below mentioned general formula. Chemical formula I [General formula (I)] (see fig. I) (wherein, substituents thereof typically include, R1, R4, R13 representing hydrogen atom, an alkyl group, a haloalkyl group and so forth, R8 representing -CO-, -SO2- or single bond, R2 representing a 3-7 membered aliphatic cyclic amino group having at least one nitrogen atom, R7 representing -CO- or -SO2-, and R12 representing N- substituted valeramido group.)

L'invention concerne des agents thérapeutiques pour les maladies cardiaques; ces agents n'ont pratiquement aucune action antagoniste vis-à-vis des récepteurs de type 1 de l'angiotensine II, qui ont un effet hypotenseur. Parmi ces agents, il y a notamment ceux constitués d'ingrédients actifs à base de composés aromatiques ou de leurs sels acceptables en pharmacie, illustrés par la formule générale ci-dessous. Dans la formule chimique I (formule générale I) ¢voir fig. I!, les substituants R1, R4 et R13 représentent un atome d'hydrogène, un groupe alkyle, haloalkyle, etc., R8 est -CO-, -SO2- ou une liaison simple, R2 représente un groupe aliphatique cyclique aminé de 3-7 chaînons, possédant au moins un atome d'azote, R7 est -CO- ou -SO2-, et R12 représente un dérivé de substitution en N du groupe valéramido.

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