C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/572 (2006.01) A61K 31/403 (2006.01) A61K 31/675 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07D 209/88 (2006.01)
Patent
CA 2492060
The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2- propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
L'invention concerne des sels de phosphate de carvedilol comprenant des nouvelles formes cristallines de phosphate dihydrogène de carvedilol (c'est-à-dire un sel de phosphate dihydrogène de 1-(carbazol-4-yloxy-3-[[2-(o-méthoxyphénoxy) éthyl]amino]-2-propanol) et/ou un phosphate hydrogène de carvedilol, etc.), et/ou des solvates de celui-ci. L'invention concerne également des compositions contenant les sels et/ou les solvates précédemment cités, et des méthodes d'utilisation desdits sels et/ou solvates afin de traiter l'hypertension, l'insuffisance cardiaque congestive, et l'angine de poitrine, etc.
Brook Christopher S.
Chen Wei
Dell'orco Philip C.
Katrincic Lee M.
Louvet Ann Marie
Gowling Lafleur Henderson Llp
Sb Pharmco Puerto Rico Inc.
Smithkline Beecham (cork) Limited
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