Caspofungin formulations

Details Caspofungin formulations Caspofungin formulations

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61K 9/19 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2657817

The present invention relates to pharmaceutical compositions comprising a pharmaceutically acceptable salt of caspofungin as active ingredient being useful for the prevention and/or treatment of fungal infections. Said compositions additionally comprise specific bulking agents and small amounts or no amounts of an additional pH modifier and may be in a liquid or solid form, e.g. may be lyophilized compositions. Said compositions show good stability and reduced amounts of sub-visible particulate matter formed in solutions which are reconstituted from the lyophilized product.

La présente invention concerne des compositions pharmaceutiques comprenant un sel pharmaceutiquement acceptable de caspofungine comme ingrédient actif, utiles pour prévenir et/ou traiter des infections fongiques. Lesdites compositions comprennent en outre des agents densifiants spécifiques et une quantité faible ou nulle d'un modificateur de pH additionnel, et peuvent se présenter sous forme liquide ou solide, et notamment sous forme de compositions lyophilisées. Lesdites compositions présentent une bonne stabilité et renferment une quantité réduite de particules non visibles à l'oeil nu formées dans des solutions reconstituées à partir du produit lyophilisé.

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