Catalytic anti-factor viii allo-antibodies

Details Catalytic anti-factor viii allo-antibodies Catalytic anti-factor viii allo-antibodies

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 31/145 (2006.01) A61K 38/08 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) C07K 7/06 (2006.01) C07K 14/755 (2006.01) C07K 16/36 (2006.01) G01N 33/543 (2006.01) G01N 33/557 (2006.01) G01N 33/558 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) C07K 14/81 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2379818

The present invention relates to a method of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor VIII molecule by said catalytic anti-Factor VIII allo-antibodies. It also relates to an anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor; and to a pharmaceutical composition comprising said catalytic anti- Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination; and further to a pharmaceutical composition comprising said anti-Factor VIII allo-antibody- catalysed Factor VIII degradation inhibitor. Finally, the present invention relates to the application in therapeutics of said anti-Factor VIII allo- antibody-catalysed Factor VIII degradation inhibitor, of a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination, and of a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor.

La présente invention concerne une technique permettant de déterminer la présence d'allo-anticorps catalytiques du facteur VIII capables de dégrader le facteur VIII chez un mammifère, et de caractériser les sites de restriction dans la molécule de facteur VIII grâce à ces allo-anticorps. Cette invention concerne aussi un inhibiteur de la dégradation du facteur VIII catalysée par l'allo-anticorps de facteur VIII, et une composition pharmaceutique qui comprend ces allo-anticorps catalytiques de facteur VIII capables de dégrader le facteur VIII et qui sont issus de cette technique de détermination. Cette invention concerne encore une composition pharmaceutique comprenant cet inhibiteur de la dégradation du facteur VIII catalysée par l'allo-anticorps du facteur VIII, une composition pharmaceutique comprenant ces allo-anticorps catalytiques de facteur VIII capables de dégrader le facteur VIII et issus de cette technique de détermination, et une composition pharmaceutique comprenant cet inhibiteur de la dégradation du facteur VIII catalysée par l'allo-anticorps du facteur VIII.

Affiliated with

Also associated with

Rating

Catalytic anti-factor viii allo-antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Catalytic anti-factor viii allo-antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Catalytic anti-factor viii allo-antibodies will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2004367